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differential hematology management acidosis lactic oncology rheumatology typea typeb activation algorithm approach arteritis cell common criticalcare cvid dehydrogenase elevated elevation
Lactic Acidosis - Classification and Differential Diagnosis Type A Lactic Acidosis: Inadequate Oxygen Delivery • Anaerobic muscular
Lactic Acidosis - Classification ... and Differential Diagnosis ... hypoperfusion, Shock ... delivery: Hypoxemia, Anemia ... Infection, Leukemia, Lymphoma
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Deficiency • Aplastic Anemia ... • Anemia of Chronic ... Non-lmmune #Anemia ... #Classification
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... - Differential Diagnosis ... Causes of Lactate ... 30mmHg) - Severe anemia ... #typeb #classification
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
history • Young adults ... Weight loss • Anemia ... Immune hemolytic anemia ... ) Classification ... #diagnosis #classification
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... e.g. lupus, CLL, lymphoma ... - Drugs (Beta lactam ... #hematology #anemia
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... - Differential Diagnosis ... Microangiopathic hemolytic anemia ... - Pernicious anemia ... Malignancy: • Lymphomas
Tachypnea - Differential Diagnosis Framework Definitions • Tachypnea: Respiratory rate > 20/min, shallow breathing in adults •
- Differential Diagnosis ... shallow breathing in adults ... Tachypnea: • Anemia ... • Hypovolemic shock ... #Differential #Diagnosis
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
- Differential Diagnosis ... Cardiogenic & Septic Shock ... , Severe Anemia, ... Malignancy (Leukemia/Lymphoma ... Difficult to diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
hepatitis • Lymphoma ... • Nodules • Lymphoid ... severe community-acquired ... autoimmune hemolytic anemia ... DDX - Other causes
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
the secondary or acquired ... arthritis (sJIA) • Adult-onset ... with leukopenia, anemia ... Triglycerides • ↑ Lactate ... Activation #Syndrome #Diagnosis
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