Lactic Acidosis - Classification and Differential Diagnosis Type A Lactic Acidosis: Inadequate Oxygen Delivery • Anaerobic muscular activity: Exercise, Generalized convulsions • Tissue hypoperfusion: Cardiac arrest, Regional hypoperfusion, Shock • Reduced tissue oxygen delivery: Hypoxemia, Anemia Type B Lactic Acidosis: No Evidence of Inadequate Tissue Oxygen Delivery • Associated with underlying disease: Diabetic failure, Hepatic failure, Infection, Leukemia, Lymphoma, Pancreatitis, Renal failure, Short bowel syndrome, Thiamine deficiency • Associated with drugs and toxins: Acetaminophen, Anti-retroviral drugs, Beta-agonists, Biguanides, Carbon monoxide, Cyanide, Epinephrine, Fructose, Isoniazid, Lactate-based dialysate, Metformin, Methanol, Nitroprusside infusion, Salbutamol, Salicylates, Sorbitol • Associated with inborn errors of metabolism doi: 10.1177/0885066620982585 #Lactic #Acidosis #Classification #Differential #Diagnosis #TypeA #TypeB #lactate
