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differential comparison dermatology management algorithm aptt bleeding bruising canimorsus capnocytophaga clinical deficiencies deficiency disseminated druginduced hemostasis intravascular lupus petechiae petechial
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
of Factor IX Acquired ... Post-partum • Acute DIC ... - Septic shock, ... #comparison #diagnosis ... #hematology #deficiency
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (16%) • Shock ... Treat primary cause ... - APTT < 1.5 x normal ... #diagnosis #causes ... treatment #management #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Diagnosis Algorithm ... deficiency - Abnormal ... fulminans - DIC ... Complete blood count coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... inhibitor of a coagulation ... discern these causes ... disease • Acute DIC ... #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Acquired deficiency ... (DIC) c. ... #diagnosis #differential ... #hematology #coagulation
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... Manifestations: Malar rash ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Capnocytophaga Canimorsus Skin Rash 40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
dogs & latter can cause ... gram-negative bacillus cause ... endocarditis, sepsis, shock ... inflammation persist → DIC ... the key to the diagnosis
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