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management dermatology rheumatology comparison algorithm ana cardiology criticalcare cutaneous differential lupus skin antibodies arteritis arthritis autoantibodies canimorsus capnocytophaga clinica common
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... • +ANA can be seen ... likely it will be clinically ... Kumfer @AnnKumfer #Antinuclear ... #diagnosis #differential
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... -15% If SLE is clinically ... erythematosus #diagnosis ... table #ANA
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
can only be confirmed ... suspicion is required ... features: Fever -, Systemic ... features: Fever +, Systemic ... #table
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... GCA can present ... Can always stop ... them, but urgent rheumatology ... w/in 24 hours) required
Capnocytophaga Canimorsus Skin Rash 40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
air conditioning system ... endocarditis, sepsis, shock ... possible Patient's clinical ... the key to the diagnosis ... #clinical #photo
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
-> 40 years • Can ... to 8 years Clinical ... severe community-acquired ... hemolytic anemia) • Systemic ... hypogammaglobulinemia #immunology #hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
affected joint • Systemic ... erythematosus (SLE) - Antinuclear ... (to support a diagnosis ... ANA and RF (if clinical ... laboratory #workup #diagnosis
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
(cutaneous or systemic ... perstans • A form of acquired ... multiforme • Acute systemic ... Erythemas #comparison #table ... #differential #diagnosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
5-6th Decades (can ... ab • RF • Antinuclear ... salivary ducts Clinical ... Central nervous system ... Nephrogenic DI Hematologic
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... months to years) Systemic ... sle #comparison #table ... #rheumatology # ... diagnosis #management
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