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management infectiousdiseases differential aids amebiasis hematology hiv infections inflammatory iris leukemia lifecycle lymphocytic neurology parasite reconstitution rheumatology treatment 1 acanthamoeba
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
Secondary to sustained immune ... , CD3, CD8 - Loss ... of CD5 and/or CD7 ... be CD4+ but this ... hemepath #pathology #diagnosis
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
Difficile Infection (CDI ... Toxic Megacolon, Shock ... Perforation) Pathophysiology ... post-ABx, but can ... be community-acquired
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
- Differential Diagnosis ... Disease by CD4 ... Count: Any CD4 ... Seasonal influenza CD4 ... Blastomycosis CD4
Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology Risk factors: - Low CD4 count - Disseminated OI -
Inflammatory Syndrome ... (IRIS) - Pathophysiology ... factors: - Low CD4 ... of innate and acquired ... #Inflammatory #Syndrome
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... that disrupts immune ... Purtilo (XLP) Acquired ... Others: Cellular immune
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... cell enzymes - Acquired ... hemolytic anemia, PNH, immune ... • Pneumocystis pneumonia ... • Tumor lysis syndrome
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
ART ↑ improves CD4 ... low pretreatment CD4 ... occur at any CD4 ... an increase in CD4 ... Depends On: • CD4
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune ... phenomenon CLL Diagnosis ... surface molecules: CD5 ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Amebiasis - Balamuthia mandrillaris Life Cycle 1) Cysts 2) Trophozoite 3) Mitosis 4) Amebae (cysts and trophozoites) can enter humans
trophozoites) can ... with compromised immune ... mandrillaris #LifeCycle #diagnosis ... #pathophysiology ... infectiousdiseases #cdc
Emphysematous Cystitis Epidemiology: • Usually middle-aged diabetic women • Other RF: neurogenic bladder, urinary tract outlet obstruction,
urinary catheter and immune ... Pathophysiology: ... Coli, but can also ... clostridium, klebsiella pneumoniae ... pyelonephritis CMC
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