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differential management treatment algorithm hematology hemophagocytic hlh lymphohistiocytosis pulmonary 1 abscess acute cap cardiology cdi cdiff childhood clostridioides clostridium community
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
rash; symptoms of shock ... , pharyngitis; pneumonia ... Streptococcus pneumoniae ... otitis media; pneumonia ... peds #pediatrics #pathophysiology
Community Acquired Pneumonia - Presenting Features • History in favor of CAP: Dyspnea, Cough, particularly if
Community Acquired ... Pneumonia - Presenting ... if productive, Fever ... criteria: Septic shock ... #Pneumonia #diagnosis
Causes of Acute Onset Fever - Differential Diagnosis Algorithm Viral: • Rhinovirus • Influenza Virus • Parainfluenza
Causes of Acute ... Diagnosis Algorithm ... Bacteremia Septic Shock ... Infection • Pneumonia ... #Algorithm #causes
Tachypnea - Differential Diagnosis Framework Definitions • Tachypnea: Respiratory rate > 20/min, shallow breathing in adults •
- Differential Diagnosis ... Asthma • COPD • Pneumonia ... • Hypovolemic shock ... • Temperature/FEVER ... #Differential #Diagnosis
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... - Differential Diagnosis ... Bacteremia/Septic Shock ... Infection #Fever ... #Algorithm #Causes
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
• Most common cause ... Lung Abscess Pathophysiology ... : • 80% have fever ... Intervention: - Fevers ... #differential #causes
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Deficiency) - Diagnosis ... Vitamin C is required ... Ill temper • Fever ... , or any other cause ... #VitaminC #AscorbicAcid
Causes of Myocarditis 1. Infectious Myocarditis • Bacterial - Staphylococcus, Streptococcus, Pneumococcus, Meningococcus, Gonococcus, Salmonella, Corynebacterium
Causes of Myocarditis ... tuberculosis), Mycoplasma pneumoniae ... more commonly cause ... Radiation, Electric Shock ... #differential #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Auto-amplification loop Diagnosis ... • Clinical: fever ... Purtilo (XLP) Acquired ... Drugs, Unknown cause
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
mucus, Abd pain, Fever ... Toxic Megacolon, Shock ... Perforation) Pathophysiology ... can be community-acquired ... Ileus, Megacolon, Shock
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