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diagnosis nephrology causes classification lactate management high potassium syndrome typea typeb aniongap criticalcare diabetes elevation encephalopathy gitelman hypokalemia insipidus neurology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis Causes of High-anion Gap Acidosis: • Lactic acidosis
Non-anion Gap Metabolic ... : • Lactic acidosis ... Renal acidosis ... aniongap #NonGap #Metabolic ... #Acidosis #differential
Lactic Acidosis - Classification and Differential Diagnosis Type A Lactic Acidosis: Inadequate Oxygen Delivery • Anaerobic muscular
Lactic Acidosis ... hypoperfusion, Shock ... Pancreatitis, Renal ... inborn errors of metabolism ... #Differential #
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... infusions) - Metabolic ... acidosis - Hyperkalemia ... Hypoaldosteronism • Acquired ... #differential #
Classification of Diabetes Insipidus Central or neurogenic diabetes insipidus: - Congenital - Structural malformations affecting the hypothalamus
- Primary renal ... Obstructive uropathy, Metabolic ... , hypercalcemia) ... Treatment is aimed ... Nephrology #Diagnosis #Differential
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Acidosis - Differential ... impairment of cellular metabolism ... sweat) - its metabolism ... ->treatments include ... #Differential #
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Hyperkalemia - Differential ... infusions) - Metabolic ... acidosis - Hyperkalemia ... Hypoaldosteronism • Acquired ... #differential #
Lactic Acidosis - Differential Diagnosis Framework Type A: Impaired O2 Delivery (DO2) • Decreased O2 Delivery: Hypotension
Lactic Acidosis ... Cardiogenic & Septic Shock ... liver Failure, Renal ... Inborn Errors of Metabolism ... #Acidosis #Differential
5-Oxoprolinuria What is it: • Aka pyroglutamic acidosis, Intermediate in γ-glutamyl cycle • Amino acid transport and
Aka pyroglutamic acidosis ... Inborn errors of metabolism ... oxoprolinase • Acquired ... • Liver and renal ... undetectable • Lactic
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
(renal potassium ... ratio 0.5%) Differential ... Sjögren syndrome, Renal ... tubular acidosis ... Rhabdomyolysis Treatment
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Infection/Sepsis/Shock ... Immunosuppressive agents, Renal ... Blood transfusion, Hypercalcemia ... Reversible course Differential ... Drug toxicity, Metabolic
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