6 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
(>1000): • DILI ... Drug-induced liver injury ... Ischemic Hepatopathy (shock ... Differential #Diagnosis #hepatology ... #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... Failure Infections Alcohol-Associated ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... Failure #Cirrhosis #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Induced Liver Injury ... involvement, Kidney injury ... non-essential drug/HDS treatments ... HEV, EBV, CMV), Alcohol-related ... Diagnosis #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Hepatic artery: Shock ... VZV • Trauma: Shock ... • Iatrogenic: DILI ... ALT Ratios: • Alcoholic ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Failure (ALF ... ALT Ratios: • Alcoholic ... Unconjugated Bili ... #differential #Hepatology ... #transaminitis
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Acute kidney injury ... HCV, DILI, HCC, ... Multiorgan failure or shock ... Management #Algorithm #hepatology