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management pharmacology antifungal infections infectiousdiseases treatment coccidioides coccidioidomycosis diagnosis fusarium agents antibiogram antibiotics antifungals azoles clinical comparison coverage cutaneous dermatology
Antifungal Azoles - Antibiotics Class Overview Mechanism: inhibit ergosterol synthesis (important component of fungal cell membranes)
Isavuconazole(PO ... #Posaconazole #Isavuconazole
Spectrum of activity for systemic antifungal agents Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
fluconazole; ISA, isavuconazole
Fusarium Treatment • Antifungal "susceptibility" can vary with Fusarium spp • F. oxysporum: low MICS to
posaconazole, isavuconazole
Fusarium Infections Acquired through: 1. Inhalation of airborne conidia > germinates > blood > disseminated 2. Trauma (implantation with
posaconazole, isavuconazole
Overview of antifungal agents benefits, weaknesses, and adverse effects in the treatment of Coccidioidomycosis. Fluconazole - Low
peripheral edema Isavuconazole
Antifungal agents benefits, weaknesses, and adverse effects in the treatment of Coccidioidomycosis Fluconazole - Benefits: Low cost/tolerable
peripheral edema Isavuconazole
Cutaneous Mucormycosis Eschar 30 M HIV cd4 10 VL 30k traumatic injury of arm few months ago
Posaconazole or isavuconazole
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
posaconazole or isavuconazole
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