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diagnosis differential hepatology dermatology systemic dili generalized pruritus bileduct biliary bilirubin congenital dilatation dilated distention drug druginduced hepatitis hyperbilirubinemia idiosyncratic
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... presentation • Chronic ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... disease, Hepatic ischaemia ... e.g. ascites), Chronic ... #Algorithm #hepatology
Causes of Biliary Dilatation - Differential Diagnosis • Physiological: ↑ Age, Cholecystectomy, Opioid dependence, Post-sphincterotomy •
Causes of Biliary ... Inflammatory: Chronic ... pancreatitis, PSC (or secondary ... Parasitic infection, Ischaemic ... #gastroenterology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis Algorithm ... Systemic and Primary Causes ... Creatinine & BUN: • Chronic ... Pruritus #primary #secondary ... #causes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... Vascular Causes ... : > 3 • Chronic ... #hepatology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... discoloration) • Liver ... discoloration) • Chronic ... #Diagnosis #Algorithm ... #causes
Abdominal Distention - Differential Diagnostic Algorithm Ascites Bowel Dilatation Other Causes Mechanical Obstruction • Adhesions 60% • Volvulus 3% •
Abdominal Distention ... Dilatation Other Causes ... Hypothyroidism Chronic ... Infectious • Ischemic ... Sclerosis, Spinal Injury
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
• Cholestatic liver ... Creatinine & BUN: • Chronic ... #Pruritus #secondary ... #generalized #dermatology ... #causes
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
of hemolysis or liver ... injury ... symptoms, such as abdominal ... and stress may cause ... #diagnosis #gastroenterology
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