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diagnosis differential causes injury lfts transaminitis aih coagulation comparison deficiencies druginduced elevated function hematology hepatocellular liverenzymes liverinjury severe summary table
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury ... - Ichemic hepatitis ... - Autoimmune ... -1 antitrypsin deficiency ... #Differential #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
disease, Hepatic ischaemia ... dechallenge • Acute ... steatosis • Autoimmune ... hepatitis #DILI ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Hepatopathy • Acute ... Viral Hepatitis ... (>1000): • DILI ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... obstruction syndrome • Autoimmune ... : DILI, Tylenol, ... See Updated Schema ... Diagnosis #causes #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... Celiac disease • Autoimmune ... : Autoimmune hepatitis ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Autoimmune ... • AIH • A1AT deficiency ... • Alcoholic hepatitis
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
) • Advanced Liver ... Alcohol, Viral hepatitis ... , Autoimmune • ... Post-partum • Acute ... catastrophes, Acute
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Other: NAFLD, Autoimmune ... hepatitis, Acute ... Diagnosis #Causes #Acute ... #algorithm #hepatology
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis of Autoimmune ... factors - Possible ischemic ... ) or metabolic liver ... 1 antitrypsin deficiency ... #Hepatology #AIH
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Vascular: Ischemic ... Other: NAFLD, Autoimmune ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
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