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differential liver lfts transaminitis injury causes abnormal acute ah autoimmune chemistry chronic cirrhosis criteria druginduced failure function gastroenterology hepatocellular interpretation
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure Infections Alcohol-Associated ... Hepatitis (AAH) ... Liver Injury (DILI ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Drugs • AIH ... hepatitis • Drugs ... Others #LFTs #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... - Differential Diagnosis ... (>1000): • DILI ... liver injury) • Ischemic ... #hepatology #transaminitis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Elevated Transaminases ... - Differential Diagnosis ... • Iatrogenic: DILI ... See Updated Schema ... #causes #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
) - Stepwise Diagnosis ... Algorithm DILI ... HEV, EBV, CMV), Alcohol-related ... disease, Hepatic ischaemia ... #Algorithm #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
- Differential Diagnosis ... Algorithm for Transaminitis ... Drugs, Viral, Ischemia ... kwburak #LFTs #Elevated ... #diagnosis #hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
of Alcoholic Hepatitis ... factors • Possible ischemic ... #diagnosis #Alcoholic ... #Hepatitis #AH ... #hepatology #criteria
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... factors - Possible ischemic ... #Diagnosis #Hepatology ... #AIH
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular ... • Iatrogenic: DILI ... specificity to elevated ... ALT Ratios: • Alcoholic ... #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Failure (ALF ... specificity to elevated ... ALT Ratios: • Alcoholic ... liver #chemistry #diagnosis ... #differential #Hepatology
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