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diagnosis differential causes lfts management transaminitis injury ascites hematology treatment acute elevated saag abnormal aclf ah aih albumin autoimmune chemistry
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Hepatitis > ... , Toxic Hepatitis ... cirrhosis, Portal ... 5-10x normal - Chronic ... #Injury #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... serologic evidence of hepatitis ... viremia or have cirrhosis ... Chronic Hepatitis ... #HepatitisB #HBV
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
EBV, CMV), Alcohol-related ... Hepatic ischaemia ... hepatitis fibrosis ... • Autoimmune hepatitis ... #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... • Autoimmune hepatitis ... See Updated Schema ... Transaminases #hepatitis ... Diagnosis #causes #hepatology
Hepatitis B Disease Progression Timeline • > 90% of infected children progress to chronic disease (<5%
Hepatitis B Disease ... develop Liver Cancer ... develop cirrhosis ... #HepatitisB #Disease ... Timeline #Prognosis #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... • Chronic Viral ... Hepatitis Moderate ... • Acute Viral Hepatitis ... injury) • Ischemic
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... Sarcoidosis Toxic - Alcohol ... Nonalcoholic fatty liver ... heart failure (chronic
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 Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Infectious • Hepatitis ... Hepatitis • Autoimmune ... Hepatitis • Drug ... Induced Hepatitis ... #Causes #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... Hepatitis, TPN ... Sepsis, Viral Hepatitis ... #hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... or fibrosis • Cirrhosis ... mg/dL) or acute liver ... failure #HepatitisB ... Indications #management #hepatology
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