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diagnosis differential hematology injury rheumatology vasculitis acute classification cvid diffuse dili druginduced hiv hypogammaglobulinemia immunodeficiency immunology lfts liverenzymes lymphadenopathy management
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... for alternative causes ... Hepatic ischaemia ... hepatitis fibrosis ... #hepatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Tuberculosis • Hepatitis ... Bleeding, Infection, Fatigue ... Age > 50 • Chronic ... Lymphadenopathy #LAD ... #Causes #Hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Renal Failure • Liver ... Epstein-Barr Virus • Hepatitis ... • HIV Autoimmune ... #Chronic #Fatigue
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... , HBV, HCV, HEV, ... > 2 • NASH, Chronic ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Alcoholic hepatitis ... Bile Ducts • Common ... #Causes
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Encephalopathy (25%) • Fatigue ... Hepatomegaly - Liver ... infection - Most common ... infection • Viral hepatitis ... load Confirmatory
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... disease • Liver ... diseases and hepatitis ... DDX - Other causes ... Malignancies • Chronic
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Purpura, ischemic ... Eosinophilia, asthma, chronic ... tract, and often causes ... • Fevers • Fatigue ... • HBV HCV •
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... an underlying cause ... normal/high - Chronic ... about secondary causes ... workup, think about common
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Fevers • Fatigue ... Nodosa: • PAN most commonly ... HTN • Check: HBV ... Eosinophilia, asthma, chronic ... tract, and often causes
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