10 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... Hepatic ischaemia ... dechallenge • Acute ... #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Trauma: Shock liver ... • Iatrogenic: DILI ... See Updated Schema ... Differential #Diagnosis #causes ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Injury (DILI) ... #Acute #Chronic ... #Cirrhosis #Hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Diagnosis and Management ... Algorithm • ... HAV immunity; Liver ... #HBV #Algorithm ... #Treatment #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Vascular Causes ... of Acute Liver ... , HBV, HCV, HEV, ... #hepatology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... liver failure ... #HBV #Treatment ... #Indications #management ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... , Acute biliary ... Differential #Diagnosis #Causes ... #Acute #algorithm ... #hepatology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
- Management Algorithm ... exclude other causes ... HCV, DILI, HCC, ... #Management #Algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
viral hepatitis ... serologies, HCV ... viral hepatitis ... ALF): • Liver ... #differential #Hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... = nonspecific (nausea ... 10x ULN), ↑Tbili/Dbili ... Diagnosis: Viral Hepatitis ... #Pregnancy #hepatology