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diagnosis differential management aflp albumin alcoholic causes chemistry chronic cirrhosis druginduced fatty gradient hepatitis injury interpretation lfts obgyn obstetrics pathophysiology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Liver Failure ( ... Injury (DILI) ... #Cirrhosis #Hepatology ... #gastroenterology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ischaemia ... dechallenge • Acute ... disorder (e.g. ascites ... #hepatology
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Differential Diagnosis Algorithm ... Infiltrative disease • Acute ... liver failure ... Post-Hepatic: • Heart failure ... #Hepatology #causes
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... liver failure rapidly ... develops (DIC, ascites ... 10x ULN), ↑Tbili/Dbili ... #Pregnancy #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Failure ( ... ALF): • Liver ... Unconjugated Bili ... > 90% of Total Bili ... #differential #Hepatology
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
- Massive liver ... Fulminant hepatic failure ... Veno-occlusive disease - Acute ... associated with bowel ischemia ... Differential #Diagnosis #hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
blood, urine and ascites ... Treatment: - Acute ... HCV, DILI, HCC, ... - Multiorgan failure ... #hepatology
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