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diagnosis differential causes injury lfts transaminitis management ascites chronic hepatitisb saag treatment albumin chemistry dili druginduced elevated failure function gap
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 20x normal - Acute ... normal - Infection (EBV ... CMV), Alcoholic cirrhosis ... #Injury #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Trauma: Shock liver ... obstruction syndrome • Autoimmune ... hepatitis • Iatrogenic ... See Updated Schema ... Diagnosis #causes #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... (DILI) Viral Hepatitis ... #Acute #Chronic ... #Cirrhosis #Hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury ... - Ichemic hepatitis ... - Drug-Induced liver ... - Autoimmune ... #Differential #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
, HBV, HCV, HEV, ... Hepatic ischaemia ... dechallenge • Acute ... steatosis • Autoimmune ... #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
and Management Algorithm ... viremia or have cirrhosis ... HAV immunity; Liver ... #HBV #Algorithm ... Management #Treatment #Hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... severe liver injury ... > 3 mg/dL) or acute ... liver failure ... Indications #management #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... Hepatopathy • Acute ... Viral Hepatitis ... injury) • Ischemic ... Differential #Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... C, A, E, B, D, EBV ... Other: NAFLD, Autoimmune ... hepatitis, Acute ... #algorithm #hepatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... • Autoimmune ... Primary Biliary Cirrhosis ... #Causes #Hepatology
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