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diagnosis hematology mds myelodysplastic acidosis aplastic classification cobalamin deficiency differential elevation lactate lactic leukostasis lysis myelodysplasia nutrition syndromes tls tumor
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... #treatment #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... - Parvovirus B19 ... Treatment: ... #oncology #hematology ... #diagnosis #management
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... wt loss • If anemia ... hypoxia and organ ischemia ... Check for IF ab Treatment ... Deficiency #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... AKI, acute limb ischemia ... organ damage • Treatment ... TLS #diagnosis #management ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... Nutritional: vitamin B12 ... #diagnosis #hematology ... #oncology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
, - regional ischemia ... - regional ischemia ... - Mesenteric ischemia ... - Compartment syndrome ... 30mmHg) - Severe anemia
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