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differential management algorithm hematology lfts transaminitis gastroenterology injury rheumatology acute ascites classification elevated nephrology abnormal biliary cardiology chronic hepatopulmonary infectiousdiseases
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 50x normal - Ischemic ... CMV), Alcoholic cirrhosis ... AST:ALT = 1 - Ischemia ... , Ischemic Necrosis ... #Injury #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... Acute Liver Injury ... - Ichemic hepatitis ... #Differential #Hepatology ... #Diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
- Differential Diagnosis ... • NAFLD • Cirrhosis ... Chronic Viral Hepatitis ... injury) • Ischemic ... #hepatology #transaminitis
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Nonalcoholic fatty liver ... disease (Budd-Chiari syndrome ... 14 percent) #Diagnosis ... #Differential #Hepatology ... #Cirrhosis #Causes
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 Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... #Algorithm #Causes
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Non-Malignant • Fatty Liver ... • Budd-Chiari Syndrome ... Primary Biliary Cirrhosis ... #Algorithm #Causes ... #Hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
those with CLD (± cirrhosis ... months without treatment ... #Failure #Cirrhosis ... #Hepatology #gastroenterology ... #management #diagnosis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
- Differential Diagnosis ... Trauma: Shock liver ... • Autoimmune hepatitis ... See Updated Schema ... #causes #hepatology
Ascites - Differential Diagnosis Chronic liver disease (cirrhosis or chronic hepatitis) - 80% Underlying malignancy - 10% Congestive heart
- Differential Diagnosis ... Chronic liver disease ... hepatitis) - 80% ... Fitz-Hugh-Curtis syndrome ... #hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... and hepatorenal syndrome ... Clues to non-cirrhotic ... /acute hepatitis ... #causes #hepatology
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