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diagnosis differential rheumatology algorithm transaminitis treatment behcet cardiology cardiotoxicity causes checkpoint cryofibrinogenemia disease elevated fungal hematology ici infections infectiousdiseases inhibitor
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
- Ischemic Hepatitis ... CMV), Alcoholic cirrhosis ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... #LFTs #transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Drugs, Viral, Ischemia ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs ... #Elevated #Abnormal ... Algorithm #diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Drugs/Toxins • Ischemia ... disease US — Normal ... Infiltrative • Cirrhosis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Purpura, ischemic ... and mesenteric ischemia ... Non-glomerular ischemia ... • Progressive symptoms ... fluid (CSF) is abnormal
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
skin injury) • Neurologic ... meningitis), MCC CNS symptoms ... retinal tears, Ischemia ... Syndrome #diagnosis #management ... #signs #symptoms
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... EGPA) • Digital ischemia ... palpable purpura 2/2 vasculitis ... or serologies + symptoms ... differential #diagnosis #management
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cooled from the normal ... Cryofibrinogenemia Symptoms ... malignancies, vasculitis ... limb and bowel ischemia ... #rheumatology #hematology
Management of Immune Checkpoint Inhibitor (ICI) Induced Cardiotoxicity Problem - Immune checkpoint inhibitors (ICIs) are associated with
Management of Immune ... pericarditis and vasculitis ... conditions including ischemia ... interventions MANAGEMENT ... heart failure management
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
ANCA-associated vasculitis ... IGG4 - Hepatic cirrhosis ... and the systemic symptoms ... phosphatase - Normal ... TAFRO #diagnosis #management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
, with ensuing ischemia ... by culture or serology ... , neutropenia, cirrhosis ... level • A low or normal ... Fungal #Diagnosis #Management
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