6 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 50x normal - Ischemic ... 5-10x normal - Chronic ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... #hepatology #LFTs
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
• NAFLD • Cirrhosis ... • Chronic Viral ... Drug-induced liver injury ... ) • Ischemic Hepatopathy ... Differential #Diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... disease, Hepatic ischaemia ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... Diagnosis #Algorithm #hepatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... changes, stroke symptoms ... AKI, acute limb ischemia ... organ damage • Treatment ... diagnosis #management #hematology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
to local skin injury ... retinal tears, Ischemia ... Arthritis, AS Treatment ... Recurrent and chronic ... #rheumatology #
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
Rheumatologic ... 85% • < 50% in chronic ... , with ensuing ischemia ... infection) • Chronic ... , neutropenia, cirrhosis