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diagnosis algorithm causes management lfts liver rheumatology ascites gastroenterology injury transaminitis abnormal albumin gradient oncology patterns pbc primary saag syndromes
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 50x normal - Ischemic ... CMV), Alcoholic cirrhosis ... AST:ALT = 1 - Ischemia ... Viral Hepatitis, Ischemic ... Liver #Injury #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Liver Injury - Ichemic ... hepatitis - Acute biliary ... Hemochromatosis - Primary biliary ... Acute #Causes #Differential ... #Hepatology #Diagnosis
Causes of Biliary Dilatation - Differential Diagnosis • Physiological: ↑ Age, Cholecystectomy, Opioid dependence, Post-sphincterotomy •
Dilatation - Differential ... sludge), Mirizzi's syndrome ... Parasitic infection, Ischaemic ... Dilatation #causes #differential ... #diagnosis #hepatology
Ascites - Differential Diagnosis Chronic liver disease (cirrhosis or chronic hepatitis) - 80% Underlying malignancy - 10% Congestive heart
Ascites - Differential ... liver disease (cirrhosis ... Fitz-Hugh-Curtis syndrome ... Failure, Pancreatic, Biliary ... #Diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... Drugs/Toxins • Ischemia ... Infiltrative • Cirrhosis ... Duct Stone • Biliary ... Others #LFTs #Hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Etiologies of Cirrhosis ... congenital - Primary biliary ... disease (Budd-Chiari syndrome ... #Diagnosis #Differential ... #Hepatology #Cirrhosis
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 Diagnosis of ascites according to the serum ascites albumin gradient (SAAG) SAAG ≥ 1.1: - Ascitic protein
protein ≤ 2.5 g/dL: Cirrhosis ... Late Budd-Chiari syndrome ... SAAG < 1.1: Biliary ... albumin #gradient #hepatology ... #differential #
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... • NAFLD • Cirrhosis ... liver injury) • Ischemic ... #Tests #LFTs #Differential ... #Diagnosis #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Drugs, Viral, Ischemia ... Congenital, Others, Cirrhosis ... - CBD stone, Biliary ... Algorithm #diagnosis #hepatology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Hepatomegaly - Differential ... • Budd-Chiari Syndrome ... Cholangitis • Primary Biliary ... Cirrhosis #Hepatomegaly ... Algorithm #Causes #Hepatology
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