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blood hepatology product reactions syndrome activation aflp apml differentiation erythematosus fatty hemophagocytic hepatitis hlh injury lupus lymphohistiocytosis macrophage mas obgyn
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... vomiting, abdominal pain ... infiltration) Differential ... Diagnosis: Viral ... #Pregnancy #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... #diagnosis #algorithm ... #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
effusions, weight gain ... • Rare: DAH, acute ... initiation • Differential ... , Anaphylaxis, Acute ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
presents as an acute ... lymph node, or liver ... agent are the main ... #management #treatment ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... permanent alopecia Differential ... Pleural effusions • Acute ... Arthritis: • Joint pain ... #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... thrombocytopenia • Liver ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
: Fever, flank pain ... maculopapular rash ... eruptions, diarrhea, liver ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
: Fever, flank pain ... maculopapular rash ... eruptions, diarrhea, liver ... #Transfusions #diagnosis ... #management #hematology
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