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liver differential lfts management transaminitis aclf causes chemistry chronic drug druginduced failure function hepatitis idiosyncratic induced interpretation pleural pulmonary rvalue
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... #differential #Diagnosis ... #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... #Hepatology #gastroenterology ... #management #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... Hepatopathy • Acute ... (>1000): • DILI ... Drug-induced liver injury ... #hepatology #transaminitis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Induced Liver Injury ... Diagnosis Algorithm ... dechallenge • Acute ... #Diagnosis #Algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular ... • Iatrogenic: DILI ... hepatitis: < 1 • Cirrhosis ... #algorithm #hepatology
Causes of Pleural Effusion - Differential Diagnosis Algorithm Transudate - Hydrostatic • Congestive heart failure • Constrictive
Causes of Pleural Effusion ... Algorithm Transudate ... - Oncotic • Cirrhosis ... • Postcardiac injury ... #Algorithm #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
hepatitis: < 1 • Cirrhosis ... Unconjugated Bili ... > 90% of Total Bili ... liver #chemistry #diagnosis ... #differential #Hepatology
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