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dili lfts management transaminitis acute biliary causes chemistry druginduced failure function hepatomegaly idiosyncratic induced interpretation pbc primary rvalue tests workup
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
(AAH) Drug-Induced ... Liver Injury (DILI ... #Cirrhosis #Hepatology ... #gastroenterology ... #management #diagnosis
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... • Drug Induced ... #Diagnosis #Algorithm ... #Causes #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Stepwise Diagnosis ... Algorithm DILI ... #Injury #Diagnosis ... #Algorithm #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... • Chronic Viral ... 1000): • DILI (Drug-induced ... liver injury) ... #Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... presentation • Chronic ... #differential # ... #algorithm #gastroenterology ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Diagnosis Algorithm ... : < 1 • Cirrhosis ... #injury #hepatitis ... diagnosis #algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Liver injury ... : < 1 • Cirrhosis ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
slightly elevated • Bilirubin ... bile ducts Differential ... Viral hepatitis, ... , Sarcoidosis, Drug-induced ... #hepatology
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