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differential lfts management acute chemistry dili failure function induced interpretation rvalue tests
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Drug-induced Liver ... presentation • Chronic ... #Injury #Idiosyncratic ... #algorithm #gastroenterology ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... #Cirrhosis #Hepatology ... #gastroenterology ... #management #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
• NAFLD • Cirrhosis ... • Chronic Viral ... 1000): • DILI (Drug-induced ... liver injury) ... #hepatology #transaminitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Liver injury ... hepatitis: < 1 • Cirrhosis ... #chemistry #diagnosis ... #differential #Hepatology ... #transaminitis
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