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diagnosis hepatology algorithm causes laboratory abscess aflp antigen carcinoembryonic cea children cholangitis cirrhosis comparison dehydrogenase disease gap globulin hellp hematology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Elevated Transaminases ... Transaminitis - Differential ... CA, small cell lung ... Trauma: Shock liver ... #Differential #
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... hyperpigmentation • Jaundice ... or higher • Liver ... bile ducts Differential ... Diagnosis: • Viral hepatitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... CA, small cell lung ... Extrahepatic - Biliary ... specificity to elevated ... #differential #
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Alcoholic hepatitis ... Duct Stone • Biliary ... #LiverEnzymes #Differential
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Pruritus, Mild jaundice ... , Elevated bile ... Syndrome (Hemolysis, Elevated ... hepatology #obstetrics #hepatitis ... #comparison #differential
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... RBCs, muscle, liver ... Prosthetic valves Lung ... Pneumonia • Other lung ... #differential #
Carcinoembryonic antigen (CEA) • CEA is a highly glycosylated cell surface glycoprotein involved in intercellular adhesion
associated with elevated ... Rectum, Breast, Lung ... Rectal polyps, Hepatitis ... cirrhosis, Obstructive jaundice ... laboratory #oncology #differential
Pyogenic liver abscess in children Common bacterial causes in children: • S.aureus • Strep spp • Enteric
Pyogenic liver abscess ... from contiguous focus ... perinephric abscess) • Biliary ... pediatrics #children #peds ... #differential #
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Elevated Globulin ... Work-up of an Elevated ... Sarcoidosis) • Liver ... ovarian tumors, lung ... Gap #ProteinGap #differential
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