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oncology bleeding bruising classification cvid disorders gap globulin hemolysis hemolytic hodgkins hypogammaglobulinemia immunodeficiency immunology intravascular mds myelodysplasia myelodysplastic platelet protein
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... microangiopathy: Thrombotic thrombocytopenic ... e.g. lupus, CLL, lymphoma ... #Causes #differential ... #diagnosis #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Diagnosis Algorithm ... Thrombocytopenia ... - Acquired • Anticoagulation ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... Diagnosis and Workup ... changes), high MCV anemia ... #Diagnosis #Causes ... #Workup #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... result in severe anemia ... immune hemolytic anemia ... WBC count and differential ... #Workup #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
(NSHL) - (most common ... Workup: • Full ... Immunohistochemical studies (to differentiate ... #hematology #oncology ... #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
specifically immune thrombocytopenia ... autoimmune hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Most common cytopenia ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... gastric tumors • Hematology ... Comment on type ... Gap #ProteinGap #differential ... #diagnosis #hematology
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