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algorithm hemolytic bleeding classification common cvid hodgkins hypogammaglobulinemia immunodeficiency immunology intravascular leukemia lymphoma mds myelodysplasia myelodysplastic nonpalpable palpable platelet purpura
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... #Causes #differential ... #diagnosis #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... / Bruising - Differential ... Thrombocytopenia ... Platelet Function ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... iron deficiency, hemolysis ... Diagnosis #Causes ... #hematology #secondary
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... Diagnosis and Workup ... #Platelet #Disorders ... Diagnosis #Causes ... #Workup #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... with or without platelet ... Schistocytes, thrombocytopenia ... #Anemia #Differential ... #workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #Diagnosis #hematology ... #nonpalpable #dermatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... hemolysis Platelet ... anemia Indirect ... WBC count and differential ... #Workup #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
PLT: Petechiae, bruising ... - infiltrates (anemia ... , thrombocytopenia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Easy or unusual bruising ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Hodgkin Lymphoma Workup ... - Low Hb and platelets ... classification #hematology ... #oncology #management
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