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hepatology diagnosis metabolism causes congenital differential hyperbilirubinemia inherited liver unconjugated alkphos astalt biliary biochemistry chemistry cholangitis cirrhosis classification forms gastroenterology
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... • Conjugated ... Bilirubin • Unconjugated ... #Metabolism #Pathophysiology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... drug reactions) Conjugated ... conjugates (eg, ... postoperative jaundice ... neoplasms #Jaundice
Biochemistry and Metabolism of Bilirubin Hemolysis → Hemoglobin → Heme → Biliverdin → Unconjugated Bilirubin (a.k.a. "indirect
→ Biliverdin → Unconjugated ... Conjugation → Conjugated ... common bile duct Unconjugated ... , and conjugated ... Biochemistry #Metabolism #pathophysiology
Jaundice - Pathophysiology and Causes - Amy Chung, MD, MSc @AmyChung #Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... Amy Chung, MD, MSc ... @AmyChung #Jaundice ... #Pathophysiology ... #Differential #Unconjugated
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice ... an increase in conjugated ... • Increase in conjugated
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Phosphatase and Bilirubin ... cytochromes) • Unconjugated ... MRP2 transports conjugated ... bilirubin into ... #Hepatology #Pathophysiology
Inherited forms of Hyperbilirubinemia Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
pathways involved in bilirubin ... bilirubin into ... Decreased MRP2 - Conjugated ... Decreased OATP1B - Conjugated ... Hyperbilirubinemia #pathophysiology
Bilirubin metabolism and pathophysiology of jaundice #Bilirubin #metabolism #pathophysiology #jaundice #hepatology
Bilirubin metabolism ... and pathophysiology ... of jaundice # ... Bilirubin #metabolism ... #pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... hyperpigmentation • Jaundice ... slightly elevated • Bilirubin
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