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diagnosis hepatology differential lfts chemistry interpretation laboratory metabolism tests algorithm alkphos astalt biliary causes cholangitis cirrhosis congenital function gastroenterology hepatitis
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
- Pathophysiology ... • Conjugated ... Bilirubin • Unconjugated ... #Metabolism #Pathophysiology ... #hepatology #Liver
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
of hemolysis or liver ... injury ... breastfeeding jaundice ... and breastmilk jaundice ... manifest only as jaundice
Jaundice - Pathophysiology and Causes - Amy Chung, MD, MSc @AmyChung #Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... Amy Chung, MD, MSc ... @AmyChung #Jaundice ... #Pathophysiology ... #Differential #Unconjugated
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
in bone Total bilirubin ... (Conjugated/DBili ... hepatocellular injury ... Indirect bilirubin ... (Unconjugated)
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Phosphatase and Bilirubin ... cytochromes) • Unconjugated ... MRP2 transports conjugated ... bilirubin into ... #Hepatology #Pathophysiology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... • Bilirubin - ... week • Direct bilirubin ... : ~ 1 Unconjugated ... Elevation: • Bilirubin
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
injury < 26 weeks ... • Bilirubin - ... week • Direct bilirubin ... Elevation: • Bilirubin ... blood cells Unconjugated
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... cholestasis → Cirrhosis/Liver ... hyperpigmentation • Jaundice ... slightly elevated • Bilirubin ... or higher • Liver
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