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diagnosis hematology management algorithm chronic classification differential disorders hodgkins lymphocytic pathophysiology workup agglutinin alkpos anaplastic anemia cancer centralretinalartery cold comparison
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... • Age: 60-80 Clonal ... (SLL) CLL Symptoms ... lymphoma #Leukemia ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... with no early symptoms ... lymphoproliferative ... cell leukemia ... leukemia #CLL
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
typically of B-cell ... involved) • No leukemic ... Reed Sternberg cell ... based on: - Cell ... type (B cell, T
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphomas and Lymphoproliferative ... pattern of spread, B symptoms ... common - T Cell ... ~10% - B-Cell ... Treated Like Acute Leukemias
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
(CLL) - Summary ... immunophenotype Clinical ... Transformation to large cell ... lymphoma (Richter ... uw_IMresidency #CLL
Post-Transplantation Lymphoproliferative Disorders (PTLD) Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
Post-Transplantation Lymphoproliferative ... PTLD) Definition: Lymphoid ... hematopoietic cell ... Epidemiology: Lymphoma ... #Disorders #oncology
Anaplastic large cell lymphoma, ALK+ Clinical • First 3 decades of life, M>F • Often nodal +
Anaplastic large cell ... Clinical • First ... subtle • Small cell ... variant can have leukemic ... advanced stage + B symptoms
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
malignancy (CLL ... Viral Infection Clinical ... malignancies - B-cell ... malignancies -> CLL ... significance (MGUS), CLL
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
from mature B cells ... accounts for 10% of all ... - Clinical Presentation ... ingestion • B symptoms ... classification #hematology #oncology
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
Pathogenesis and clinical ... -> Endothelial cell ... Disease: (i.e. leukemia ... /lymphoma, sickle ... cell, polycythemia
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