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management neurology differential hematology cll lymphocytic signs spinal spinalcord algorithm als amyotrophic behcet comparison disease disorders hemeonc hodgkins lesions lymphoma
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... onset of symptoms ... • Age: 60-80 Clonal ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... cytometry → >500/uL clonal ... immunophenotype Clinical ... #oncology #hematology ... #hemeonc #diagnosis
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
injury - Multiple sclerosis ... Lower motor neuron symptoms ... Upper motor neuron symptoms ... are spared Conus ... #differential #diagnosis
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
combination of the clinical ... cellular function Clinical ... multiple spinal cord ... Jaw Jerk reflex, Clonus ... fasciculations Common Symptoms
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
- Differential Diagnosis ... neurological lesion: Clinical ... Tract Lesions: • Bilateral ... : - Multiple sclerosis ... Scleroderma, Systemic sclerosis
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Hyperreflexia, Clonus ... Diagnosis - Based ... patients with clinically ... stimulation Clinical ... Progressive MS (Spinal cord
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Orange or Hep C Clinical ... with no early symptoms ... #CLL #Chronic ... #oncology #hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... Hyperreflexia develops later ... signs and/or symptoms ... suggestive of multiple sclerosis ... : - Multiple sclerosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Autoimmune diseases • Clinical ... involved) • No leukemic ... cell, T cells, natural ... Differential Diagnosis ... NonHodgkins #comparison #oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... matter, spinal cord ... Behcet syndrome (Clinical ... tears, Ischemia, Leukemia ... Recurrent and chronic
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