18 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver, bone ... • softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... Skeletal: - Bone
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
inflammatory disorder of bone ... inflammation of the bones ... • Bone and joint ... Rule out other causes ... osteoarticular and skin disease
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
Differential Diagnosis Algorithm ... • Cushing's Disease ... Chemotherapy • Bone ... Celiac, IBD) • ... endocrinology #causes
Osgood-Schlatter Disease - MSK Radiology
Imaging Findings:
 • Infrapatellar fat-pad edema with loss of the patellar tendon
Osgood-Schlatter Disease ... fragmentation and mild ... bone marrow edema ... marrow edema and bony ... #mri #clinical
Bilateral B-Lines in case of Pneumonia on Lung POCUS

Young healthy pt with fever/dyspnea. POCUS lung exam
Bilateral B-Lines in case ... POCUS lung exam done ... interstitial lung disease ... Robert Jones @RJonesSonoEM ... #Lung #POCUS #clinical
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... accumulation of clinical ... , Biological + Bone ... Assessment • Clinical ... /ml, ↑ LDH • Bone
Notice that there are multiple densities in both lungs.
The larger ones are ill-defined and maybe there
The larger ones ... are ill-defined ... consolidations, but one ... masses. ... #Clinical #Radiology
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
pathogenesis and clinical ... vast majority of cases ... phosphorous in bones ... Pseudogout #CPPD #Disease
Langerhans Cell Histiocytosis (LCH)

Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
particular affinity for bone ... areas include the bones ... pituitary gland • Bone ... ribs, and long bones ... Liver, Spleen, Bone
Nontuberculous Mycobacteria (NTM) Infections 

Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
• Domestic and wild ... status NTM Cause ... ) - Bone Marrow ... : Clinical Manifestations ... : • Clinical (