9 results
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Anticoagulants Common ... - Warfarin (Coumadin ... Kcentra) - Heparin/LMWH ... Protamine sulfate - Dabigatran ... #noac #pharmacology
Anticoagulant specific factor inhibition. 

#anticoagulation #clotting #INR #heparin #LMWH #NOAC #warfarin #coumadin #rivaroxaban  #Xarelto #apixaban
Anticoagulant specific ... #INR #heparin #LMWH ... #NOAC #warfarin ... #coumadin #rivaroxaban ... apixaban #Eliquis #dabigatran
Oral Anticoagulation Management Cheat Sheet: Warfarin, Apixaban, Dabigatran, Rivaroxaban
 - Mechanism of Action
 - Routine Blood
Management Cheat Sheet: Warfarin ... , Apixaban, Dabigatran ... , Rivaroxaban ... Adjustrnent - Reversal ... Anticoagulation #Anticoagulant
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
e.g. rivaroxaban ... e.g. warfarin) for ... : A new oral anticoagulant ... #UFH #DOAC #Dabigatran ... #Fondaparinux #NOAC
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Anticoagulant Agents ... Warfarin - 100% ... Hepatic, 25% Renal Dabigatran ... Hepatic, 50% Renal Rivaroxaban ... #NOAC #Metabolism
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
stratification algorithm ... , edoxaban and rivaroxaban ... anticoagulants ... LMWH = low molecular ... #Cancer #Algorithm
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... Apixaban, Edoxaban or Rivaroxaban ... modified factor Xa • Dabigatran ... #Reversal #NOAC ... #Oral #anticoagulant
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
thrombosis in cancer ... initiated after a LMWH ... ¥LMWH is currently ... DOAC, direct oral ... #Cancer #Algorithm
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
For patients on warfarin ... direct acting oral ... anticoagulants ... of Therapy • Dabigatran ... Apixaban, Edoxaban, Rivaroxaban