10 results
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Agents - Warfarin ... Kcentra) - Heparin/LMWH ... anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
Oral Anticoagulation Management Cheat Sheet: Warfarin, Apixaban, Dabigatran, Rivaroxaban
 - Mechanism of Action
 - Routine Blood
, Apixaban, Dabigatran ... , Rivaroxaban ... Adjustrnent - Reversal ... Anticoagulant #DOAC ... #Management #Table
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... #DOAC #Bridging ... Anticoagulation #Dabigatran ... #Apixaban #Rivaroxaban ... #Pharmacology #Hematology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
, edoxaban and rivaroxaban ... filtration rate; DOAC ... anticoagulant; LMWH ... #DOAC #VTE #Malignancy ... #Cancer #Algorithm
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... not available #DOAC ... #Reversal #NOAC ... #Oral #anticoagulant ... #hematology #management
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
the mainstay of VTE ... (e.g. heparin, LMWH ... anticoagulant (e.g. warfarin ... #UFH #DOAC #Dabigatran ... #Fondaparinux #NOAC
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
Weight Heparin (LMWH ... Enoxaparin - Warfarin ... inhibitors - Apixaban, rivaroxaban ... ) inhibitors - Dabigatran ... #medications #doac
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
for VTE in Malignancy ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... #Cancer #Algorithm ... Anticoagulation #Management #Hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... ) Cancer-treatment ... Dabigatran has moderate ... content/133/4/291 #DOAC ... #Interactions #Table
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
For patients on warfarin ... direct acting oral ... determine timing of DOAC ... per treatment table ... postoperative #DOAC