11 results
Oral Anticoagulation Management Cheat Sheet: Warfarin, Apixaban, Dabigatran, Rivaroxaban
 - Mechanism of Action
 - Routine Blood
Sheet: Warfarin ... , Apixaban, Dabigatran ... , Rivaroxaban ... Anticoagulant #DOAC ... Pharmacology #Stop #Perioperative
Anticoagulant specific factor inhibition. 

#anticoagulation #clotting #INR #heparin #LMWH #NOAC #warfarin #coumadin #rivaroxaban  #Xarelto #apixaban
#INR #heparin #LMWH ... #NOAC #warfarin ... #coumadin #rivaroxaban ... apixaban #Eliquis #dabigatran ... #Pradaxa #management
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
Novel (or Direct) Oral ... Anti-Coagulants • Rivaroxaban ... • Apixaban • Dabigatran ... Prescribing #hematology #management ... #Direct #Oral #
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Reversal Agents - Warfarin ... Kcentra) - Heparin/LMWH ... Protamine sulfate - Dabigatran ... Edoxaban (Lixiana), Rivaroxaban ... #noac #pharmacology
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
of Clearance of Oral ... Anticoagulant Agents Warfarin ... Hepatic, 25% Renal Dabigatran ... Hepatic, 50% Renal Rivaroxaban ... #NOAC #Metabolism
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
(e.g. heparin, LMWH ... anticoagulant (e.g. warfarin ... - Rivaroxaban ... #UFH #DOAC #Dabigatran ... #Fondaparinux #NOAC
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
Weight Heparin (LMWH ... Enoxaparin - Warfarin ... inhibitors - Apixaban, rivaroxaban ... ) inhibitors - Dabigatran ... comparison #table #management
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Perioperative Management ... For patients on warfarin ... direct acting oral ... of Therapy • Dabigatran ... Apixaban, Edoxaban, Rivaroxaban
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
stratification algorithm ... , edoxaban and rivaroxaban ... direct-acting oral ... anticoagulant; LMWH ... Anticoagulation #Management
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
Apixaban, Edoxaban or Rivaroxaban ... modified factor Xa • Dabigatran ... #Reversal #NOAC ... #Oral #anticoagulant ... #hematology #management