13 results
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Algorithm - Urinary Chloride ... loop or thiazide diuretics ... suction, Congenital chloride ... pressure: Active diuretic ... Bartter syndrome, Gitelman
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... loop or thiazide diuretics ... pressure: Active diuretic ... Bartter syndrome, Gitelman ... urine #Algorithm #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
thiazide-sensitive sodium-chloride ... distal tubule. ↑ Nacl ... delivery to distal nephron ... Hypokalemia Metabolic alkalosis ... Pathophysiology #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic Alkalosis ... intake, Diuretics ... -: Diuretics, Bartter ... Syndrome, Gitelman ... Diagnosis #Algorithm #nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Thiazide or loop diuretics ... after renal tubule diuretic ... Thiazide or loop diuretics ... furosemide-like lesion) • Gitelman ... Diagnosis #Causes #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic Alkalosis ... intake, Diuretics ... -: Diuretics, Bartter ... Syndrome, Gitelman ... Diagnosis #Algorithm #Nephrology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
- Metabolic alkalosis ... RENAL LOSS: - Diuresis ... - Bartter - Gitelman ... Pathophysiology #Nephrology ... #Chloride
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
with thiazide diuretic ... hypomagnesemia • Metabolic alkalosis ... Hypochloremic metabolic alkalosis ... Surreptitious diuretic ... Syndrome #diagnosis #nephrology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... • Inhibit Na+ Cl ... loss through the nephron ... #Pharmacology # ... nephrology #conversion
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic Alkalosis ... intake, Diuretics ... -: Diuretics, Bartter ... Syndrome, Gitelman ... Diagnosis #Algorithm #Nephrology