25 results
Hemolytic anemia in Wilson's disease

#Wilsons #Disease #hemolytic #anemia #Hematology #pathophysiology
Hemolytic anemia ... in Wilson's disease ... #Wilsons #Disease ... #hemolytic #anemia ... #Hematology #pathophysiology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Sickle Cell Disease ... - Pathophysiology ... membrane proteins and activating ... #Pathophysiology ... Complications #Hematology
High Output Heart Failure - Pathophysiology and Differential Diagnosis
Obesity - Systemic Vasodilation, Vasoactive Adipokines
Arteriovenous Fistula -
Heart Failure - Pathophysiology ... Vasodilation Paget's Disease ... Vasodilation Lung Disease ... Metabolism Severe Anemia ... Differential #Diagnosis #cardiology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
in 1923 Low ALP ... Malnutrition • Wilson's disease ... • Pernicious anemia ... collection with EDTA Pathophysiology ... Hyophosphatasia #hepatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... with leukopenia, anemia ... tests ↑ AST ↑ ALT ... MAS #Macrophage #Activation ... Diagnosis #Management #Hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... but elevated as disease ... obstruction • ALP ... , IgG4 related disease ... diagnosis #workup #hepatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... IFN-y) → Excessive activation ... Griscelli, Purtilo (XLP ... • Autoimmune diseases
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
chronic liver disease ... , ALT and AST can ... deficiency - Anemia ... leads to chronic anemia ... LiverFailure #Hepatic #Hepatology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Action, ↑ EFR & AP ... Inhibit B.adrenergic activation ... inotropy) ACCP Cardiology ... Classification #Classes #pathophysiology ... #cardiology
Anemia of Chronic Disease - Pathophysiology
One theory to explain why "anemia of chronic disease" exists:
The inflammatory
Anemia of Chronic ... Disease - Pathophysiology ... of chronic disease ... #disease #hematology ... #pathophysiology