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diagnosis hematology differential causes abnormal aptt prolonged anticoagulant anticoagulation apixaban bleeding bruising cascade clot dabigatran disseminated edoxaban hemostasis heparin inhibitor
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... protein C and S Pathophysiology ... Fibrinogen: ↓ • PT ... 100mg/dL) - Heparin ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
unfractionated heparin ... cause e.g. heparin ... (DIC) c. ... #differential #hematology ... #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... intravascularcoagulation (DIC ... #differential #hematology ... #coagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... #Coagulation #Cascade ... thrombin #clot #PT ... #pathophysiology ... Rivaroxaban #Edoxaban #heparin
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... Acquired: • Heparin ... Warfarin • Acute DIC ... intravascular coagulation ... disease • Acute DIC
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Albumin • Coagulation ... factors: PT/INR ... replaced by non-hepatic ... Hemolysis #liver #chemistry ... #differential #Hepatology
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