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diagnosis hematology causes differential abnormal aptt anticoagulant anticoagulation bleeding bruising cascade clot dabigatran dic disseminated edoxaban hemostasis heparin inhibitor intravascular
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
- Rivaroxaban, apixaban ... unfractionated heparin ... cause e.g. heparin ... #differential #hematology ... #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... protein C and S Pathophysiology ... Fibrinogen: ↓ • PT ... treatment #management #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... thrombin #clot #PT ... #pathophysiology ... thrombin #inhibitor #Apixaban ... Rivaroxaban #Edoxaban #heparin
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and aPTT If ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... #differential #hematology ... #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... Acquired: • Heparin ... prolonged after ... intravascular coagulation ... Differential #Diagnosis #Hematology
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