5 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... e.g. heparin ... #differential #hematology ... #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
PT and aPTT If ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... #differential #hematology ... #coagulation
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... protein C and S Pathophysiology ... Fibrinogen: ↓ • PT ... #diagnosis #causes
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... thrombin #clot #PT ... #pathophysiology ... anticoagulant #Warfarin #Dabigatran ... Rivaroxaban #Edoxaban #heparin
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... Acquired: • Heparin ... , dabigatran, argatroban ... prolonged after ... discern these causes