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diagnosis management hematology differential syndrome algorithm gastroenterology cirrhosis hepatopulmonary hyperbilirubinemia hypertension injury metabolism acromegaly activation aflp alkaline alkphos alp arterial
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... • Conjugated Bilirubin ... #Metabolism #Pathophysiology ... #hepatology #Liver
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... Phosphatase and Bilirubin ... initial insult Bilirubin ... ASTALT #AlkPhos #Bilirubin ... #Hepatology #Pathophysiology
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
non-ICU vs ICU causes ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct #bilirubin ... gastroenterology #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... hepatocellular injury • Bilirubin ... week • Direct bilirubin ... Elevation: • Bilirubin ... diagnosis #algorithm #hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
function: INR, bilirubin ... sarcoidosis) • Liver ... metastasis • Fatty liver ... Differential #Diagnosis #causes ... #hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
of hemolysis or liver ... birth with serum bilirubin ... associated with bilirubin ... and stress may cause ... #hepatology #diagnosis
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... Pregnancy (AFLP) Pathophysiology ... = nonspecific (nausea ... #Pregnancy #hepatology ... diagnosis #management #pathophysiology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Hepatitis B - Treatment ... infection with severe liver ... injury (INR > 2, bilirubin ... mg/dL) or acute liver ... Indications #management #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... slightly elevated • Bilirubin ... or higher • Liver ... diagnosis #workup #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... non-essential drug/HDS treatments ... for alternative causes ... Alcohol-related liver ... Diagnosis #Algorithm #hepatology
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