46 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology ... #comparison
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Antitrypsin • Other: NAFLD ... Syndrome, Celiac Disease ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... Acute #algorithm #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Wilson's, HH, NAFLD ... 5x ULN - NAFLD ... Ducts - PBC ... Algorithm #diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... ALT < 5x ULN • NAFLD ... • Cholestatic disease ... Bile Ducts • PSC ... Others #LFTs #Hepatology
Non-alcoholic fatty liver disease algorithm.
 
For those patients with NAFLD or liver disease of unknown aetiology,
disease algorithm ... or liver disease ... disease; NFS, NAFLD ... NonAlcoholic #FattyLiver #Disease ... Referral #Management #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Venoocclusive disease ... Autoimmune hepatitis, PBC ... stone, Malignancy, PBC ... disease: > 2 ... diagnosis #algorithm #hepatology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Folate deficiency, Liver ... Abetalipoproteinemia, Liver ... Artifact, Uremia, Liver ... stomatocytosis, Liver ... differential #diagnosis #hematology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
disturbance (obstructed liver ... Highest • Bone • Liver ... biliary Cholangitis (PBC ... - PSC - Other ... Diagnosis #Algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology ... cholestasis → Cirrhosis/Liver ... but elevated as disease ... or higher • Liver ... diagnosis #workup #hepatology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
female-predominant disease ... of autoimmune disease ... relative with PBC ... Cholestasis #PBC ... #hepatology