8366 results
Leigh Syndrome 
History: 19-month-old girl with hypotonia, developmental 
delay, failure to thrive, and bilateral optic disc
Leigh Syndrome ... MarkMamloukMD #Leigh ... #Syndrome #Clinical
Amiodarone induced thyroid changes

Histopath: Remarkably enlarged follicles, distended with colloid, without 
scalloping, and lined by flattened
lipofuscin) AIT ... are two types of AIT ... pertechnetate scanning Weigh ... thyrotoxicosis #AIT ... #Pathology #Clinical
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
or AST > ALP): ... • Severe - ALT ... Viral, Ischemia, AIH ... • Moderate - ALT ... or AST): • US
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Injury • AST ... /ALT elevation > ... Alk phos • ALT ... and kidney) Is it ... • R value = (ALT
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis Clinical ... Highly variable clinical ... + AST > 10x ULN ... - ALT + AST > ... mild laboratory, clinical
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... of jaundice - AST ... >50, AST/ALT >1.5 ... or >400 IU/L, AST ... /ALT <1.5), ANA
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
R-value: Serum (ALT ... /ULN ALT) / (Alk ... to liver than ALT ... : ↑ • ALT: ↑ ... /ALT: typical of
Dropped Foot Gait - Paralysis of Dorsal Flexion of the Foot.
When trying to walk the tip
Dropped Foot Gait ... It is found in lesions ... This type of gait ... leg excessively, at ... #PhysicalExam #clinical
Parkinsonian Gait 

Parkinson's gait is very characteristic: Standing, the patient tends to tilt the trunk forward,
Parkinsonian Gait ... Parkinson's gait ... During gait, it ... in starting the gait ... #PhysicalExam #clinical
Hemiplegic Gait 

With a hemiplegic gait there is impaired natural swinging at the hip and knee
Hemiplegic Gait ... With a hemiplegic gait ... natural swinging at ... #Hemiplegic #Gait ... #PhysicalExam #clinical