7340 results
Leigh Syndrome 
History: 19-month-old girl with hypotonia, developmental 
delay, failure to thrive, and bilateral optic disc
Leigh Syndrome ... MarkMamloukMD #Leigh ... Clinical #MRI #Brain #Diagnosis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
- Differential Diagnosis ... or AST > ALP): ... • Severe - ALT ... or AST): • US ... Transaminitis #Algorithm #diagnosis
Amiodarone induced thyroid changes

Histopath: Remarkably enlarged follicles, distended with colloid, without 
scalloping, and lined by flattened
lipofuscin) AIT ... are two types of AIT ... pertechnetate scanning Weigh ... thyrotoxicosis #AIT
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Injury • AST ... /ALT elevation > ... Alk phos • ALT ... • R value = (ALT ... Transaminitis #diagnosis
Features of Components of Liver Function Tests #Diagnosis #IM #GI #LFTs #Liver #Function #Tests #Locations #AlkPhos
Function Tests #Diagnosis ... Locations #AlkPhos #AST ... #ALT #Ddxof
Liver Function Tests (LFTs)
 - Aspartate aminotransferase (AST) 
 - Alanine aminotransferase (ALT) 
 - Alkaline
aminotransferase (AST ... aminotransferase (ALT ... LFTs #Laboratory #Diagnosis
Standardized Physical Abuse Guideline
<6 months of age
 • Social work consult
 • Skeletal survey
 • Head
, ALT, lipase ... Abdominal CT if AST ... months of age if AST ... or ALT> 80, signs ... Peds #Pediatrics #Diagnosis
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... of jaundice - AST ... >50, AST/ALT >1.5 ... /ALT <1.5), ANA ... Autoimmune #Hepatitis #Diagnosis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
R-value: Serum (ALT ... /ULN ALT) / (Alk ... : ↑ • ALT: ↑ ... /ALT: typical of ... liver #chemistry #diagnosis
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Diagnosis - If suspected ... , AIH diagnosis ... + AST > 10x ULN ... - ALT + AST > ... #Diagnosis #Management