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diagnosis management differential lupus workup chronic comparison druginduced erythematosus hemophagocytic hlh leukemia lymphocytic lymphohistiocytosis oncology polycythemia sjogrens syndrome table treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... and Management Summary ... Manifestations: Malar rash ... #lupus #Systemic ... #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... rendering the immune system ... non-Hodgkin lymphoma SLL ... Scoring system: ... workup #oncology #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... NPSLE rare, Malar rash ... months to years) Systemic ... Manifestations: Malar rash ... comparison #table #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
lymphoma, B-cell ... Autoimmune diseases: SLE ... Drugs, Unknown cause ... management #treatment #summary ... #rheumatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... Too many cells in ... frequently affected systems ... Better call hematology ... #workup #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... Central nervous system ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... CRP GCA (Giant Cell ... , mucositis • Rash ... tract, and often causes ... Differential #Diagnosis #Rheumatology
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