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diagnosis hematology management antiarrhythmics cardiology classes classification hypokalemia algorithm anemia aplastic differential gitelman hemeonc hemophagocytic hlh leukemia leukostasis lymphohistiocytosis lysis
Causes of Hypokalemia - Differential Diagnosis Algorithm Increased Loss - Increased GI Loss - Increased Urinary
Causes of Hypokalemia ... - Refeeding Syndrome ... Diagnosis #Algorithm #causes ... #potassium #low ... #pathophysiology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... skin that are caused ... Out Secondary Causes ... #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... may result from low ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... : • Pathophysiology ... Lysis of tumor cells ... , Elevated Cr, Low
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
repolarization CLASS 3 - Potassium ... ++ influx into cells ... Vaughan #Williams #Pharmacology ... Classification #Classes ... #pathophysiology
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... repolarization CLASS 3 - Potassium ... Antiarrhythmics #Pharmacology ... Classification #Classes ... #pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Intracellular Urate, Potassium ... #Oncology #Diagnosis
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
apical membrane of cells ... alkalosis • Normal or low ... Supplement: • Potassium ... #diagnosis #nephrology ... #management #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... caused by uncontrolled ... Pathophysiology ... Low/absent NK-cell ... Diagnosis #Management #Hematology
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