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diagnosis hematology nephrology anemia aplastic apml cancer causes classification differentiation emergencies gitelman hodgkins leukostasis lymphoma lysis mds myelodysplasia myelodysplastic oncologic
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
- Differential ... of breath • Neurologic ... neutrophil count < 500 cells ... renal failure • Hypocalcemia ... #differential #
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Framework and Management ... kidney tubular cells ... Rhabdomyolysis #Differential ... #Diagnosis #Management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
occurs due to a low ... occurs due to a low ... blood count with differential ... #diagnosis #hematology ... #oncology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
apical membrane of cells ... alkalosis • Normal or low ... ratio 0.5%) Differential ... #diagnosis #nephrology ... #management #pathophysiology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... may result from low ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Lysis of tumor cells ... , Elevated Cr, Low ... hydration - Hyperkalemia ... TLS #diagnosis #management ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Release from blast cells ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Blood Count - Low ... may be high or low ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
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