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diagnosis dermatology differential leukemia management algorithm aml anemia antimda5 antimda5dm antinxp2 antinxp2dm aplastic autoimmune chronic clinical cll disorders eosinophil eosinophilia
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... ulcerations • Skin ... #rheumatology #
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophilia, 500-1,500 cells ... Hypereosinophilia, >1,500 cells ... organ-specific signs ... symptoms (eg, skin ... Differential #diagnosis #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Episcleritis Signs ... , breast CA - Hematologic ... multiforme - Dermatomyositis ... Syndrome #diagnosis #dermatology ... #oncology
Leukemic skin Infiltrate: Patient with known Acute Myelogenous Leukemia presented with diffuse bullous lesions (not shown). These
Leukemic skin Infiltrate ... of leukemic cells ... Goldberg, M.D. - UCSD ... Images #Clinical #Photo ... #Dermatology #SkinRash
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Hepatomegaly • Skin ... : - CLL cells ... diagnosis #workup #oncology ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... number of CD34+ cells ... number of CD34+ cells ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
have typical DM skin ... chest (in a V-sign ... shoulders (in a shawl sign ... ulcerations • Skin ... diagnosis #management #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Rapidly rising blast cells ... : Granulocytic cells ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
caused by blood cells ... just beneath the skin ... , and the cells ... Syndromes #diagnosis #hematology ... #oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Purpura, ischemic skin ... purpura: Strong sign ... Multinucleated giant cells ... cmpkx deposits skin ... Differential #Diagnosis #Rheumatology
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